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What most likely explains a rash that is raised, itchy, and appears/disappears in various locations?

Purpura

Urticaria, or hives

The presence of a rash that is raised, itchy, and has the characteristic of appearing and disappearing in different locations most closely aligns with urticaria, commonly known as hives. Urticaria is an allergic response that causes a release of histamine and other chemicals in the skin, leading to the formation of wheals—raised, often red or skin-colored bumps that can vary in size. These wheals can indeed shift locations on the body and may resolve and reappear quickly, aligning perfectly with the description provided.

This transient nature of the rash, along with its itchiness and raised appearance, distinguishes urticaria from other conditions. While purpura involves discoloration due to bleeding under the skin, it does not typically present with itching or a changeable pattern. Psoriasis is usually chronic, with plaques that do not resolve or relocate quickly, and is characterized by silvery scales rather than transient wheals. Insect bites may cause localized reactions but typically do not result in the extensive and migratory rash described in this question.

Psoriasis

Insect bites

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